Engineering Lactobacillus rhamnosus GG and GR-1 to express HIV-inhibiting griffithsin

Have you ever wonder if we can use recombinant bacteria to prevent and treat HIV infections?

Cloning techniques are never as easy as you might think, especially when working with Lactobacillus species. After more than six years working on this complex in vitro system to expressed anti-HIV molecules, we were able to obtain a few recombinant strain with a potential to inhibit HIV infections. If you want to learn more take a look at our recently published article at the International Journal of Antimicrobial Agents. Link to the article can be found here